Hodgkins Disease Essays - Anatomical Pathology, RTT,

Hodgkin's Disease Hodgkins Disease Cancers arising from the lymph nodes or other sites of lymphoid tissue are broadly termed lymphomas. This group of diseases is divided into Hodgkins disease and non-Hodgkins lymphoma. In both conditions, there is a replacement of normal lymphatic tissue by collections of abnormal lymphoma cells. The lymphatic system are a complex network of specialised cells and organs that defend the body against infection. Lymphatic organs include the bone marrow, spleen, thymus gland, lymph nodes, tonsils, adenoids, appendix and clumps of tissue in the small bowel. A function of the lymphatic system is to nurture and mature the B and T-lymphocytes (white blood cells vital to immune function). Cancerous changes can take place when mutation leads to failure of the cells maturing of the lymphoid cells. Lymphomas are regarded as cancers of lymphocytes. The process which lymphoma occurs consists of a series of events where normal lymphocyte cells cease to mature and develop in an orderly fashion. The genetic make-up of the lymphocyte is altered, resulting in the formation of altered lymph tissue (tumours) or altered lymphocyte secretions. Typically, patients present with a painless swelling of lymph node, with or without fever and night sweats and weight loss. How Hodgkins Is Caused. The exact cause of Hodgkins disease isnt known. However, different of how it is caused. 1. Viruses The Epstein-Barr virus is a herpes virus that causes infectious mononucleosis (also known as glandular fever). Epstein-Barr virus genes have been identified in tissue samples of approximately 20-50% of individuals with Hodgkins disease. However, it is yet to be established whether the Epstein-Barr virus can cause Hodgkins disease. The most of people who develop glandular fever will not develop Hodgkins disease. 2. Genetics Hodgkins disease is associated with a number of rare immune disorders. Chronic inflammatory disorders such as rheumatoid arthritis and systemic lupus erythematous have also been associated with Hodgkins disease. Further, the recipients of heart, kidney and other organ transplant have been found to be at an increased risk of developing the illness. There is some evidence suggesting that first degree relatives of individuals with Hodgkins disease is at a small, but increased risk of developing the disease. However, Hodgkins disease is not directly heritable. Involved nodes in the neck, groin and armpits tend to be painless, firm, and rubbery. In some instances, the nodes may spontaneously increase and decrease in size. Because Hodgkins disease is associated with a defect in the maturation of the lymphocyte, the immune system may be impaired. As such repeated infections may occur. Symptoms The symptoms of Hodgkins disease frequently depend upon the stage of disease. Staging defines the extent to which the disease has spread throughout the body. Moreover, it often determines which treatment(s) will be required. Hodkins has 4 distinct stages of Hodgkins disease, these being stages 1-4. Each stage is further defined as exhibiting either A or B symptoms. These symptoms refer to either the absence of A or presence of B unexplained weight loss in the preceding 6 months, fever greater than 38?C, and or night sweats. Tumour suppressor genes: In health this family of genes usually act as a counter balance for oncogenesis. It is thought that they may be responsible for repairing gene damage in cells, or are growth inhibitor genes. In Hodgkins disease, there are often evidences of mutation in tumour suppressor genes as well as other genes. Stage 1. Stage 1 Hodgkins disease affects a single lymph node or lymph node region. The lymph nodes most commonly affected are the nodes in the neck, armpits or groin. Stage 2. Stage 2 disease is associated with lymph node involvement in 2 or more regions. However, the nodes must be involved in only one side of the diaphragm. The diaphragm is a muscle lying beneath the lungs. It moves up and down allowing air to move in and out of the lungs. Stage 3. Stage 3 disease is associated with lymphoma involvement on both sides of the diaphragm. The spleen is frequently involved at this stage. If the spleen is involved the abdomen may become tender or enlarged, with or without symptoms of abdominal fullness and distension. Stage 4. When Hodgkins disease enters stage 4, disease can spread through the body to area outside of the lymphatic system.

internal and external negoitating essays

internal and external negoitating essays Internal and External Negotiating .... The Pie Contradiction. When the discussion on this type of topic comes up, it is important to understand several key points. First is the fact that negotiations of this nature are done by one group (or institution) to another group. Now, knowing this it is also safe to assume that groups of people are not a collective of one mind and one thought, and thus the group will not act as one. Inside these groups, many different and sometimes conflicting ideas and interests are bound to hinder a straightforward negotiation. These internal problems creeping into the wood work before the other party has even made in to the table will ultimately create new layers in the bargaining process. This is not to say all internal negotiations are bad. In my opinion if a group will argue between them to smooth out all the potential internal interests and concerns; then it can also be sure that as a group the entire entity was come to the bargaining table with the knowledge that all of its main views have already been addressed. Then as a result the bargainer knows what as a group they would accept and decline. As it was briefly covered in the article the internal bickering within one group does have its downfalls which in the long run hinder the group more then promote it. If certain people within the group have personal agendas such as personal wealth or influence in mind, these views of the few that can go against the optimum deal for the entire group. Then as these people fight to have their views and solutions pushed forward the group may lose more in the long run. (Albeit the few people in the group may come out even stronger.) I believe the key to getting beyond the internal negotiations and out onto the bargaining table with the other party is to as a group not bicker over 1 or 2 minor things, but to look at these deals one pie which may have many different ingredients within it. The pi...

Navigation Incident NO.1 Essay Example | Topics and Well Written Essays - 1000 words

Navigation Incident NO.1 - Essay Example The buoy however was unharmed. DISCUSSION MV â€Å"Calamity Jane† was proceeding at a speed of 15 knots along the course of 170o (T). Visibility was determined to be good and with an excess of 10 nautical miles. The tidal stream was estimated to be setting 178o (T) at a rate of 1.4 knots. Even all of the bridge equipments such as the radar were fully functional. With everything working in top form, MV ‘’Calamity Jane’s’’ route was fully planned and she was on schedule, passing her first way point ‘’Mew Island Lighthouse’’ and enroute to the second way point ‘’South Rock Lighthouse’’. The distance between the previous way points was 18.3 nautical miles. The plan of passage was marked up on the chart (No.2093) and it determined that the ship was to proceed at a course of 170o (T) at 15 knots so that to pass between the South Rock Light Vessel, until South Ridge buoy. On passing the previous w ay point the ship was scheduled to alter her course to 210o (T) and follow up this course for 7.5 nm so as to reach ‘’Strangford Narrows Leading Lights’’, her third way point. Things began to get out of hand about 18 minutes prior to midnight, which was scheduled to be the time for switching watches between the two navigators. The 1st navigator fixed the position of the ship at 2342 and 2348 but found that the ship was 2 cables east of track while the South Rock Light Vessel was ahead of the track. This led to him altering 5o to starboard and then following up a new course of 175o (T). Subsequently, the 1st navigator took a third fix right before switching watches at 2354 and found that the ship was back on track. This incident is said to have occurred mainly due to the faults by the first navigator, who first took two fixes in a 6 minutes interval, which is good. He noticed that the ship was in the port side of the track and so made alterations to the sta rboard to a course of 175o (T) to regain the track. However, he did not consider the effects of the tidal stream that was estimated to be setting 178o (T) at a rate of 1.4 knots. Considering the course and the direction of the tidal stream together, it is understood that the ship will drift most towards the east because of the lack of resistance between the tidal stream and the ship flow. Thus, this lack of consideration of this aspect could have resulted in a largely misleading from the planned track and beginning to drift off the course. Then, less than 6 minutes before midnight, the 1st navigator tried to correct things by taking a last fix and found that the ship was right on track while navigating at the same course at 175o (T). Now, the ship was momentarily on track but not following the correct course since it was drifting towards the west. The navigator’s timing for takinf the fix was quite bad and turned out to be unfortunate for the ship. Had the fix been made even a few minutes later, the 1st navigator would have noticed that he was proceeding on the wrong course and that the ship was wrongly drifting towards the west. This is considered wrong since the east coast plays a better home for ships than the west due to the west having more hazards such as shallow water, wreck and unlit buoy which are almost impossible to notice in the dark. The 1st navigator did not consider all this while making the decision and this accident was caused due to his lack of attention.

Ancient and MEdieval Political Theory Essay Example | Topics and Well Written Essays - 5000 words

Ancient and MEdieval Political Theory - Essay Example Furthermore, it is evident that the US, possesses negative relation with certain countries that has led towards ineffective foreign policy and decision-making. On the other hand, there are also many nations having positive relation with the US and hence, lead to effective development of foreign policies and decision making regarding the elimination of terrorism from the world. Thus, from the evidences and the arguments of the research, it is asserted that the states’ identity in foreign policy and decision-making has led to limited efficiency in demolishing terrorism from the world. The objective of the research emphasizes identifying the identity of the US with regard to its active participation in the fight against terrorism. More elaborately, it intends to discover the role of the US in combating terrorism. The report also focuses on discovering the importance of foreign policies and decision making along with the international relationship in soliciting global power for combating terrorism. It is expected that by accomplishing these objectives, the report would lead to the development of a comprehensive understanding regarding the role of the US and correspondingly, its identity in designing foreign policies and decision-making. Hence, the discussion would lead towards soliciting global support, which would be further effective in combating terrorism. Several studies have been conducted with regard to the research topic, as elaborated in the following sections of the paper. These studies were highly successful with regard to the identification of state identity in fighting against terror groups. Research studies have also been concentrated on extensively considering the foreign policies and decision-making in soliciting global support to combat terrorism from the world. However, there are very little evidences of research studies that consider both these aspects. Therefore, the rationale behind the study is to grasp the opportunity of

Supply Chain Strategy Essay Example for Free

Supply Chain Strategy Essay What recent changes have caused supply chain management to gain importance? 2. With so much productive capacity and room for expansion in the United States, why would a company based in the United States choose to purchase items from foreign firm? Discuss the pros and cons. The use of foreign firms can provide a U. S. firm more alternatives in selecting a supplier. The pros are more choices, potentially reduced costs in the areas of materials, transportation, production, and distribution, and potentially moving closer to a foreign market. The cons are the distance is generally increased, communications problems are increased due to distance, culture, and technology. There may be problems with customs, government regulations, political stability, etc. 3. Describe the differences between functional and innovative products. Functional products are staples that people buy in a wide range of retail outlets. Typically, they do not change much over time, have low profit margins, stable predictable demand and long life cycles. Innovative products, on the other hand, give customers additional reasons to buy. Fashionable clothes and personal computers are examples of innovative products. Innovative products have short life cycles, high profit margins, and volatile demand. 4. What are characteristics of efficient, responsive, risk-hedging and agile supply chains? Can a supply chain be both efficient and responsive? Risk-hedging and Agile? Why or Why not? As a supplier, which factors would you consider about a buyer (your potential customer) to be important in setting up a long-term relationship? The financial stability and credit worthiness of the company is of primary importance. The reputation of the company visavis their supplier is also very important. For example, is this a company that is fair with its suppliers and honors its payables in a timely fashion? Is the technological match between supplier and customer sufficient? Will delivery schedules and quantities be stable, facilitating smooth operations? For the value density example in Exhibit 10. 9, what would the effect be if a competing firm offers you a similar service for 10 percent less than Federal Express’s rates? 7. What are the advantages of using the postponement strategy? Process postponement delays the process step that differentiate the product to as late in the supply chain as possible. The advantages of this approach are that lower levels of inventory, and fewer models are needed to match customer requirements. This results in higher levels of customer satisfaction at a lower cost.

The Passing of the Crown by Shakespeares Henries Essay -- Henry IV He

The Passing of the Crown by Shakespeare's Henries      Ã‚  Ã‚   In his histories from Richard II through Henry V to Richard III, Shakespeare depicts the English monarchy as a game between family and friends of vying for a gold ring -- the crown. Shakespeare gives his reader a central metaphor through which to see this equation in King Henry IV part one. The prank Prince Hal, later King Henry V, and his friend, Poins, play on their friends, particularly Falstaff, parallels the plot's focal passing of the crown.    In the first act, Poins outlines his plan to play a prank on Falstaff and their other friends to Prince Hal, "They [Falstaff and others] will adventure upon the exploit [of stealing money from travelers] themselves, which they shall have no sooner achieved but we'll set upon them" (I.ii.169-71). This exactly represents the larger action that takes place in this same piece. King Henry IV, previously Bolingbroke, usurped the crown from King Richard II in Shakespeare's play of that title, and now, in this King Henry Hotspur is trying to take from "Bolingbroke," the name he contemptuously insists on using for the king, the crown which the king 'rightfully' stole already. Hal's prank can, in fact, be seen as the summarizing play within the play so popular in Elizabethan drama. Not only does Hal's light-hearted game sum up the events of this history, it also works as a microcosm of the events in King Richard III, a tragedy wherein Richard steals the throne from his brothers, Ed ward and George, who, in turn, stole it from Henry VI. The metaphor becomes even more obviously applicable when we hear Falstaff's self-defense for giving up the stolen money so easily, "Was it for me to kill the heir apparent?"... ...taining the position and participating in its ceremonies is a game. However, I don't think this means that the role is an impossible one to actually possess, that it's always simply an unreachable construct that everyone pretends at. I think it just means that Shakespeare sees the crown as not being as serious a thing to possess as is commonly thought. It's a joke, a gag, a prank, always a gold ring made of cardboard. Where there's "a kingdom for a stage," so too can there be 'a stage for a kingdom' (Henry V, prologue line 3). Being King means playing.    Works Cited Shakespeare, William. Henry IV: part one. Ed. P. H. Davison, New York: Penguin Books, 1996. Shakespeare, William. Henry IV: part two. Ed. P. H. Davison, New York: Penguin Books, 1997. Shakespeare, William. Henry V. Ed. A. R. Humphreys, New York: Penguin Books, 1996.   

Examine the theme of deception in Much ado about nothing Essay

The theme of deceit is apparent throughout the whole play and it helps to propel the plot forward. At the start of the play we are introduced to the idea that there is a gap between illusion and reality when Claudio is described as having â€Å"the figure of a lamb, the feats of a lion.† Despite being youthful, he is deceptively strong. Furthermore, â€Å"Lady Disdain† is presented to the audience as a contented maid, cynical about love â€Å"I would rather hear my dog bark at a crow than a man swear he loved me.† And Benedick is presented as a man who values his freedom and independence and proclaims that he would never succumb to marriage, he claims if he does his friends are free to â€Å"pluck off the bull’s horns and plant them in my forehead.† Both of these claims are false, as ironically, the two marry at the end of the play. The feuding pair, Beatrice and Benedick form a platform for the theme of deception as beneath the antagonism and mockery lies deep rooted emotions for each other. Their hatred is simply and illusion as a â€Å"false face† is presented to the world. Later in the play their love blossoms and Benedick’s views are ironically transformed â€Å"get thee a wife† Deception is further highlighted where Don Pedro offers to woo Hero on Claudio’s behalf. â€Å"I will assume thy part in some disguise.† Don Pedro’s dominance leaves the reticent Claudio no choice but to accept his offer and under a â€Å"mask† he woos the unsuspecting Hero. Deception is used here to form relationships. Masks are used to confuse illusion and reality in the ball Beatrice speaks openly about her thoughts on Benedick â€Å"why he is the prince’s jester† It is debatable whether Beatrice knows that Benedick is the stranger behind the mask but if she does happen to know this then she is deceiving him to make a fool out of him. In a lighter manner, Benedick and Beatrice are deceived into love by their matchmaking friends. In frivolous Messina the joy of courtship and matchmaking helps to highlight the trivial society in which they exist. Through eavesdropping they listen to false claims about love. Claudio claims that Beatrice is sick in love with Signor Benedick and â€Å"baits the fish† as they reel him in with intrigue and swelling pride. Similarly, Beatrice’s friends hope that â€Å"her ear lose nothing of the sweet bait we lay for it†¦Ã¢â‚¬  and both characters are tricked into love as their friends orchestrate a cunning plan. The most prevalent form of deception is used when the malevolent Don John uses deception to break the fragile relationship between Claudio and Hero at the climatic point of the play. He uses the male fear of cuckoldry to forge and administer his plan. Through claiming, †the lady is disloyal† he deceives his brother and encourages Claudio to believe the innocent Hero is â€Å"soiled† deceit is used here to slander an innocent maid. Rather that fall foul to the shame of infidelity, Claudio publically shames Hero and refuses her on the basis that she is a â€Å"rotten orange† again suggesting that outer appearances can be deceptive and she is rotten at the core. This sparks a catalyst for further deceit where Hero â€Å"fakes† her death. False friendships between Claudio and Benedick are exposed â€Å"I must discontinue your company.† and the calm, tolerant Leonato is unveiled to reveal a more aggressive and violent character who fears dishonour and public shame. â€Å"hence†¦let her die!† he would rather his daughter die than face the public humiliation. The tangled web of deceit continues where Leonato insists that Claudio marry his niece who is infact the â€Å"re-born† and cleansed â€Å"Hero† of the story. Claudio is deceived into thinking that his bride is dead. His willingness to accept the unknown, â€Å"Which is the lady I must seize upon?† shows that marriage for social grace is more important than love but also shows his commitment to show remorse. Finally, the very language of Much Ado about Nothing helps to illuminate the key theme of deception as the pomp of the aristocracy and the use of elaborate language encourages the audience to assume a moral and ordered society; yet lurking beneath this lies sinister and deceitful behaviour often born out of jealousy and desire.